BBC reports that Fernando Gago is also likely to start, with Maxi Rodriguez and Hugo Campagnaro set to drop to the substitutes’ bench.
Javier Mascherano will win his 100th cap, becoming the fourth Argentine to reach the landmark.
Iran could name the same team which drew with Nigeria, with Charlton’s Reza Ghoochannejhad their lone striker.
DATE: June 21, 2014
TIME: 17: 00
VENUE: Estadio Mineirao, Belo Horizonte
POSSIBLE LINE UP:
ARGENTINA: Romero; Zabaleta, Rojo, Garay, Fernandez; Gago, Mascherano, Di Maria; Higuain, Aguero, Messi
IRAN: Haghighi; Montazeri, Hosseini, Sadeqi, Pooladi; Heydari, Nekounam (c), Teymourian; Dejagah, Hajsafi; Ghoochannejhad.