Portugal welcomes back Pepe after his suspension to play for a game they must win.
However, they have injury concerns over Hugo Almeida and Helder Postiga, while the injured Fabio Coentrao is already out of the tournament.
Ghana midfielder Sulley Muntari is suspended after picking up two bookings.
Michael Essien could come in to the side for his first start of the tournament, while right-back Daniel Opare is still out injured.
DATE: June 26, 2014
TIME: 17 : 00 BST
VENUE: Estadio Nacional, Brasilia
POSSIBLE LINE UP:
PORTUGAL: Beto, Alves, Pereira, Pepe, Costa, Veloso, Miereles, Moutinho, Nani, Ronaldo, Postiga.
GHANA: Dauda; Afful, Mensah, Boye, Asamoah; Rabiu, Badu, Boateng; Atsu, A Ayew, Gyan.
Sulley Muntari will miss Thursday’s game due to suspension.